Oral HIV-associated Kaposi sarcoma

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A clinical study from the Ga-Rankuwa area, South Africa

Kaposi sarcoma (KS) is one of the most common neoplasms diagnosed in HIV-seropositive subjects.

Oral involvement is frequent and is associated with a poor prognosis.

The aim of this study was to characterize the features of oral HIV-KS in patients from Ga-Rankuwa, South Africa.

Twenty of the 37 patients in the study were females and 17 were males.

In 21 patients, the initial presentation of HIV-KS was in the mouth.

Other than the fact that females presented with larger (≥10mm) oral KS lesions, there were no statistically significant gender differences.

Significantly more patients presented with multiple oral HIV-KS lesions than with single lesions.

Nine patients developed concomitant facial lymphoedema, and these patients had a significantly lower CD4+ T cell count compared to the rest of the group.

The average CD4+ T cell count of the patients who died was significantly lower at the time of oral-KS presentation than of those who survived.

In Ga-Rankuwa, South Africa where HIV-KS is prevalent, oral KS affects similarly males and females.

A low CD4+ T cell count at the time of oral HIV-KS diagnosis and the development of facial lymphoedema portends a poor prognosis.

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