Formulation of Bilayered Floating Tablets of Atorvastatin and Niacin

56,05 €

59,00 €


Frais d'envoi limités à 4,90 € pour la France métropolitaine quel que soit le nombre d'articles. Délai de livraison : 2 à 5 jours.
Livraison dans le monde entier.

Formulation and Evaluation of Bilayered Floating Tablets of Atorvastatin Calcium and Niacin

In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood.

This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease.

Hence control of blood cholesterol levels is very much important to reduce the risk of CVD.

In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution.

This reduces the levels of LDL and triglycerides in the blood to a major extent.

On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release.

Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent.

Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia.

Plus de détails

Envoi en courrier suivi.
Livraison sous 2 à 4 jours en France et dans le monde entier.
Programme de fidélité
Votre panier totalisera 5 points fidélité vous offrant lors de votre prochain achat une réduction de 2,50 €
Avis clients
Soyez le premier à partager votre avis sur ce produit