Effects of Stromal Cell Derived Factor on PTEN

34,10 €

35,90 €

-5%

Frais d'envoi limités à 4,90 € pour la France métropolitaine quel que soit le nombre d'articles. Délai de livraison : 2 à 5 jours.
Livraison dans le monde entier.

Effects of CXCL12 on Expression and SubCellular localization of PTEN in Cancer Cells

Since its discovery in 1997 by three independent groups, PTEN has become one of the most studied tumour suppressor genes.

PTEN gene encodes a 403 amino acid sequence protein which has a vital role as a negative regulator for the highly oncogenic prosurvival PI3K/AKT signalling pathway.

However, PTEN is one of the most frequently mutated tumour suppressor genes in human cancer.

Expression and subcellular localization of PTEN can be affected by certain chemokines.

This project has been carried out to study and investigate the effects of CXCL12 chemokine on the expression and subcellular localization of tumour suppressor PTEN in cancer cells.

Methods: Two cell lines with different PTEN protein profiles; human endometrial carcinoma HEC 1B, and human neuroblastoma SH SY5Y were stimulated with 20, 50ng/ml of CXCL12.

Immunocytochemistry and Western blotting have been performed in triplicate to determine the expression and subcellular localization of PTEN before and after the CXCL12 stimulation.

Plus de détails

Livraison
Envoi en courrier suivi.
Livraison sous 2 à 4 jours en France et dans le monde entier.
Programme de fidélité
Votre panier totalisera 3 points fidélité vous offrant lors de votre prochain achat une réduction de 1,50 €
Avis clients
Soyez le premier à partager votre avis sur ce produit