EVALUATION OF THE ANTIEPILEPTIC ACTIVITY

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OF LEONOTIS LEONURUS

To investigated in L.

leonurus the anticonvulsant properties and the possible mechanism of action.

Seizures were induced in mice with injection of doses of pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid.

The ability of the plant extract to prevent or prolong the tonic hind-limb extensor reflex was assessed.

The results were statistically analyzed using the paired Student’s t-test and Chi- squared test.

L.

leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% and 50% of animals used and significantly (p0.05) delayed pentylenetetrazole-induced tonic seizures.

Similarly, the same doses of the plant extract significantly (p0.05) delayed the onset of tonic seizures produced by picrotoxin and N-methyl-DL-aspartic acid.

However, all the doses of aqueous extract of L.

leonurus used did not alter the seizures induced by bicuculline (20 mg/kg) to any significant extent.

L.

leonurus has anticonvulsant activity and may probably be acting through non-specific mechanisms, since it affects both gabaergic and glutaminergic systems.

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