• -5%
The immune modulatory effects of Rift Valley Fever strains
search
  • The immune modulatory effects of Rift Valley Fever strains
  • The immune modulatory effects of Rift Valley Fever strains

The immune modulatory effects of Rift Valley Fever strains

44,90 €
42,65 € Économisez 5%

The objective of this research was to analyse the interaction of Rift Valley Fever virus (RVFV) with the human innate immunity.

In recent work it was shown that the RVFV protein NSs, a non-structural protein, has an inhibitory effect on the interferon response of the innate immune system by blocking the interferon- (IFN-) promoter [145].

To assess the natural variability of the NSs activity the immune modulatory effects of twenty-six wild type RVFV strains isolated throughout Africa were characterized using molecular biological tools.

The diversity of these strains was also assessed by sequencing the NSs genes and by looking at their polymerisation activity in the nucleus of Vero E6 cells.It was revealed that RVFV NSs-R7 contains an additional mutation at position 344 (T to C), which leads to the replacement of leucine by proline.

This mutation seems to have a strong effect on the NSs function since NSs-R7 no longer inhibits activation of the IFN-β promoter and does not show filamentous structure formation in the nucleus of infected cells.

The results also merit to investigate the eligibility of strain R7 as a vaccine candidate.

Livraison dans le monde entier.
Frais d'envoi limités à 4,90 € pour la France métropolitaine quel que soit le nombre d'articles. Délai de livraison : 2 à 5 jours.

Quantité
Disponible

2007-2010: University of Göttingen (Germany), Faculty of Biology: Degree: Doctor of Philosophy (PhD) in Virology / Immunology, mention Honourable (magna cum lauda) October 26, 2010 for the defense and for the examination.

2003 - 2004: Institute of Tropical Medicine in Anwers (Belgium): Degree: Master of Science in Animal Health (disease control)


Fiche technique

Auteur
Marque
LAP LAMBERT Academic Publishing
Pages
132
Pays
Sénégal Sénégal

30 autres produits dans la même catégorie :

Buoyancy and Elasticity of Tax: Nigerian Perspective

Buoyancy and Elasticity of...

35,90 € 5% 34,00 €
  • -5%
Genus Solanum: Chemistry and Pharmacology

Genus Solanum: Chemistry...

39,90 € 5% 37,00 €
  • -5%
Autonomic Neuropathy in Type 2 DM Patients in Enugu Nigeria

Autonomic Neuropathy in...

49,90 € 5% 47,00 €
  • -5%
Plaidoyer en faveur de la Spiritualité

Plaidoyer en faveur de la...

41,90 € 5% 39,00 €
  • -5%
100 pensées, 2 fois. Exercice d'un libre penseur

100 pensées, 2 fois....

53,90 € 5% 51,00 €
  • -5%
KAPANGALA. LES DIAMANTS TOMBÉS DU CIEL

KAPANGALA. LES DIAMANTS...

48,90 € 5% 46,00 €
  • -5%
Modelling and Simulation of a Reversible Chemical Batch Reactor

Modelling and Simulation of...

61,90 € 5% 58,00 €
  • -5%
Teachers' Perception of the Influence of students' indiscipline

Teachers' Perception of the...

49,00 € 5% 46,00 €
  • -5%
PROBLEMY I PERSPEKTYWY REWOLUCJI ICT W ROZWOJU CZARNUCHÓW

PROBLEMY I PERSPEKTYWY...

37,90 € 5% 36,00 €
  • -5%
Знак зверя, "666", и конец света

Знак зверя, "666", и конец...

23,90 € 5% 22,00 €
  • -5%
O sinal da besta, ' 666 ', e o fim do mundo

O sinal da besta, ' 666 ',...

23,90 € 5% 22,00 €
  • -5%
Znak bestii, ' 666 ', i koniec świata

Znak bestii, ' 666 ', i...

23,90 € 5% 22,00 €
  • -5%
Het teken van het beest, "666", en het einde van de wereld

Het teken van het beest,...

23,90 € 5% 22,00 €
  • -5%
Il segno della bestia, '666', e la fine del mondo

Il segno della bestia,...

23,90 € 5% 22,00 €
  • -5%
El signo de la bestia, '666', y el fin del mundo

El signo de la bestia,...

23,90 € 5% 22,00 €
  • -5%
Das Zeichen des Tieres, ' 666 ', und das Ende der Welt

Das Zeichen des Tieres, '...

23,90 € 5% 22,00 €
  • -5%
La Cour constitutionnelle de la République du Congo : institution politique ou juridictionnelle ?

La Cour constitutionnelle...

61,90 € 5% 58,00 €
  • -5%
Сontes de grand-mère

Сontes de grand-mère

21,90 € 5% 20,00 €
  • -5%
Alpha Amylases from Fungi

Alpha Amylases from Fungi

69,90 € 5% 66,00 €
  • -5%
Le Correspondant à la Protection des données à caractère personnel

Le Correspondant à la...

54,90 € 5% 52,00 €
  • -5%
Monograph on Microbiology of Drinking Water

Monograph on Microbiology...

54,90 € 5% 52,00 €
  • -5%
Le ligament de l'entorse latérale de la cheville

Le ligament de l'entorse...

39,90 € 5% 37,00 €
  • -5%
Evaluation Of Advanced Hybrids Of Two Solanum Species

Evaluation Of Advanced...

54,90 € 5% 52,00 €
  • -5%
Factors Influencing Vasectomy Acceptability

Factors Influencing...

54,90 € 5% 52,00 €
  • -5%
Carboxymethyl Cellulase Production From Agricultural Wastes

Carboxymethyl Cellulase...

64,90 € 5% 61,00 €
  • -5%
Analysis of Poverty and Vulnerability to Poverty

Analysis of Poverty and...

39,90 € 5% 37,00 €
  • -5%
The Impact of Foreign Direct Investment

The Impact of Foreign...

54,90 € 5% 52,00 €
  • -5%
A Study on the Business Environment of MSMEs in Egypt

A Study on the Business...

54,90 € 5% 52,00 €
  • -5%
Kierkegaardian Subjectivity and African Philosophy

Kierkegaardian Subjectivity...

79,00 € 5% 75,00 €
  • -5%
An Introduction to Univariate and Multiple Time Series Analysis with R

An Introduction to...

61,90 € 5% 58,00 €
  • -5%